Chromatin looping

Across TCGA cell cohorts, RNA activity of the Chromatin looping pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INPP5J, TARBP2, and IRF2BP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chromatin looping activity versus INPP5J in OESOPHAGUS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	INPP5J →	+1.304	+1.010	.001	.002	3	5
PANCREAS	TARBP2 →	+0.602	+1.257	.002	<.001	3	5
OESOPHAGUS	IRF2BP1 →	+0.776	+0.831	<.001	.003	2	6
BLOOD_Myeloma	YWHAE →	+0.934	+1.326	<.001	<.001	3	5
BLOOD_Myeloma	PFAS →	+1.027	+1.326	<.001	<.001	3	5
OESOPHAGUS	KRBA1 →	+1.346	+0.997	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140588 vs INPP5J — OESOPHAGUS

Explore this scatter interactively →