Granzyme-mediated programmed cell death signaling pathway

Across TCGA patient cohorts, RNA activity of the Granzyme-mediated programmed cell death signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GZMK, SRGN, and GZMM, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granzyme-mediated programmed cell death signaling pathway activity versus GZMK in SKCM (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GZMK →	+2.772	+0.162	<.001	<.001	3	31
CHOL	SRGN →	+1.979	+0.117	<.001	<.001	3	31
SKCM	GZMM →	+1.636	+0.113	<.001	<.001	3	31
SKCM	CD72 →	+1.853	+0.145	<.001	<.001	3	31
SKCM	SLAMF7 →	+2.067	+0.122	<.001	<.001	3	31
SKCM	GZMH →	+2.786	+0.168	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140507 vs GZMK — SKCM

Explore this scatter interactively →