Granzyme-mediated programmed cell death signaling pathway

Across TCGA patient cohorts, RNA activity of the Granzyme-mediated programmed cell death signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOL2, FAM83E, and CXCL9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granzyme-mediated programmed cell death signaling pathway activity versus APOL2 in GBM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	APOL2 →	+0.485	+0.520	<.001	.002	3	3
UCEC	FAM83E →	-1.031	-0.501	.002	.001	3	3
LUAD	CXCL9 →	+1.371	+0.497	.005	.003	3	3
LUAD	CTDSP1 →	-0.240	-0.348	.005	.007	3	3
COAD	ARMC12 →	+0.221	+0.736	.002	.002	3	3
COAD	HPD →	+0.244	+0.817	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140507 vs APOL2 — GBM

Explore this scatter interactively →