Granzyme-mediated programmed cell death signaling pathway

Across TCGA patient cohorts, RNA activity of the Granzyme-mediated programmed cell death signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BNIP3_S151, FNBP4_T479, and GARRE1_S946, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granzyme-mediated programmed cell death signaling pathway activity versus BNIP3_S151 in PDAC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BNIP3_S151 →	+0.781	+0.935	<.001	<.001	3	4
LUAD	FNBP4_T479 →	+0.537	+0.790	<.001	.001	3	3
UCEC	GARRE1_S946 →	-0.439	-0.730	<.001	<.001	3	3
HNSC	ALS2_S1342 →	-1.086	-1.722	<.001	<.001	3	3
UCEC	MMGT1 →	+0.711	+0.762	<.001	<.001	3	3
PDAC	SEPTIN8 →	-0.268	-0.710	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140507 vs BNIP3_S151 — PDAC

Explore this scatter interactively →