Granzyme-mediated programmed cell death signaling pathway

Across TCGA cell cohorts, RNA activity of the Granzyme-mediated programmed cell death signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INCA1, IDUA, and TBX3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INCA1 grouped by Granzyme-mediated programmed cell death signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	INCA1 →	-0.592	-1.465	.004	.001	3	4
BREAST	IDUA →	-1.088	-0.637	.009	.004	2	5
URINARY_TRACT	TBX3 →	-3.642	-1.809	.006	<.001	3	3
OESOPHAGUS	GLB1L3 →	-0.936	-1.150	.006	<.001	3	3
OESOPHAGUS	MGAT2 →	-0.774	-1.071	.001	<.001	3	3
OESOPHAGUS	TCEA2 →	-1.710	-1.538	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INCA1 by Granzyme-mediated programmed cell death signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →