Integrated stress response signaling

Across TCGA patient cohorts, RNA activity of the Integrated stress response signaling pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RESF1, CSF2RB, and TNFAIP3, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Integrated stress response signaling activity versus RESF1 in UVM (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	RESF1 →	+1.569	+0.058	<.001	<.001	3	32
CHOL	CSF2RB →	+2.266	+0.068	<.001	<.001	2	32
ACC	TNFAIP3 →	+2.035	+0.038	<.001	<.001	3	31
SCLC	PTPN22 →	+1.665	+0.090	<.001	<.001	3	31
SCLC	CCR5 →	+1.775	+0.065	<.001	<.001	3	31
DLBC	CCR4 →	+2.735	+0.101	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140467 vs RESF1 — UVM

Explore this scatter interactively →