Integrated stress response signaling

Across TCGA patient cohorts, RNA activity of the Integrated stress response signaling pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYZP2, PNMA6A, and PNMA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Integrated stress response signaling activity versus CRYZP2 in CCRCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CRYZP2 →	-0.278	-0.643	.001	<.001	3	4
PDAC	PNMA6A →	-0.324	-0.419	.001	.004	3	4
GBM	PNMA3 →	-0.874	-0.838	.008	.001	3	3
CCRCC	MAN1A2P1 →	-1.083	-0.538	<.001	<.001	3	3
LUAD	FAM189A2 →	-0.428	-0.154	.005	.001	3	3
LUAD	KCNMA1-AS3 →	-0.333	-0.167	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140467 vs CRYZP2 — CCRCC

Explore this scatter interactively →