Integrated stress response signaling

Across TCGA cell cohorts, RNA activity of the Integrated stress response signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSBP, H2BC21, and MAPRE3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OSBP grouped by Integrated stress response signaling-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OSBP →	-1.132	-0.437	<.001	.001	3	4
CNS	H2BC21 →	-1.215	-0.284	.004	<.001	3	4
CNS	MAPRE3 →	-1.165	-0.226	.001	.003	2	5
SOFT_TISSUE	ACCS →	-2.205	-0.312	<.001	<.001	3	4
SOFT_TISSUE	LAG3 →	-1.442	-0.414	.002	<.001	3	4
SKIN	IQSEC2 →	-0.839	-0.297	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OSBP by Integrated stress response signaling activity — LUNG_SCLC

Explore this box plot interactively →