Integrated stress response signaling

Across TCGA cell cohorts, RNA activity of the Integrated stress response signaling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEBPB, JUN, and PPP1R15A, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Integrated stress response signaling activity versus CEBPB in BLOOD_Myeloma (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CEBPB →	+1.768	+0.130	<.001	<.001	3	17
BONE	JUN →	+2.995	+0.169	<.001	<.001	3	14
BLOOD_Myeloma	PPP1R15A →	+1.675	+0.100	.002	<.001	3	13
BREAST	GADD45A →	+2.138	+0.115	<.001	<.001	3	12
SOFT_TISSUE	DUSP1 →	+2.352	+0.130	<.001	<.001	3	12
BLOOD_Myeloma	BEST1 →	+1.638	+0.093	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140467 vs CEBPB — BLOOD_Myeloma

Explore this scatter interactively →