Integrated stress response signaling

Across TCGA cell cohorts, RNA activity of the Integrated stress response signaling pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WARS2, NCS1, and PLCE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Integrated stress response signaling activity versus WARS2 in CNS (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	WARS2 →	+0.501	+0.136	.007	.009	2	6
SKIN	NCS1 →	-0.850	-0.247	<.001	<.001	3	5
LUNG_NSCLC_LUAD	PLCE1 →	-1.095	-0.310	.003	<.001	3	4
BONE	TENT5B →	-3.157	-0.577	<.001	<.001	3	4
BONE	MTCL1 →	-3.444	-0.430	<.001	<.001	3	4
BLOOD_Lymphoma	ZNF600 →	-1.463	-0.177	<.001	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140467 vs WARS2 — CNS

Explore this scatter interactively →