Signaling receptor ligand precursor processing

Across TCGA patient cohorts, RNA activity of the Signaling receptor ligand precursor processing pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACE, MGAT4A, and CD93, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signaling receptor ligand precursor processing activity versus ACE in ESCA (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	ACE →	+1.113	+0.059	<.001	<.001	3	21
ESCA	MGAT4A →	+1.409	+0.047	<.001	<.001	3	20
HNSC	CD93 →	+1.141	+0.029	<.001	<.001	3	19
CHOL	ENPEP →	+1.506	+0.060	.001	<.001	3	19
SARC	ABCA1 →	+0.800	+0.023	<.001	.001	3	19
ESCA	SLC46A3 →	+1.188	+0.043	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140448 vs ACE — ESCA

Explore this scatter interactively →