Signaling receptor ligand precursor processing

Across TCGA patient cohorts, RNA activity of the Signaling receptor ligand precursor processing pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID2, RANBP2_S3207, and MRPL44, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signaling receptor ligand precursor processing activity versus NID2 in UCEC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NID2 →	+0.632	+0.057	.003	.001	3	8
BRCA	RANBP2_S3207 →	-0.529	-0.039	.001	<.001	3	8
BRCA	MRPL44 →	-0.366	-0.040	<.001	<.001	3	7
LSCC	RRP9 →	-0.381	-0.051	<.001	<.001	3	7
GBM	SNX9 →	+0.450	+0.064	<.001	<.001	3	7
GBM	U2SURP →	-0.314	-0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140448 vs NID2 — UCEC

Explore this scatter interactively →