Signaling receptor ligand precursor processing

Across TCGA patient cohorts, RNA activity of the Signaling receptor ligand precursor processing pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYCR1, SCN1B, and PDE2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signaling receptor ligand precursor processing activity versus PYCR1 in UCEC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PYCR1 →	-0.962	-0.191	.008	.004	3	5
GBM	SCN1B →	+0.475	+0.164	.009	.001	3	5
BRCA	PDE2A →	+0.787	+0.213	<.001	.002	3	5
LSCC	SMIM3 →	+0.617	+0.143	<.001	.008	2	6
HNSC	FGF7 →	+0.901	+0.156	.003	.001	3	4
OV	GAS1 →	+0.883	+0.185	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140448 vs PYCR1 — UCEC

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