Signaling receptor ligand precursor processing

Across TCGA cell cohorts, RNA activity of the Signaling receptor ligand precursor processing pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXT2, CD151, and TMED9, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signaling receptor ligand precursor processing activity versus EXT2 in BONE (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	EXT2 →	+1.444	+0.211	<.001	<.001	3	13
LUNG_NSCLC_LUSC	CD151 →	+2.044	+0.213	<.001	<.001	3	12
BONE	TMED9 →	+1.619	+0.225	<.001	<.001	3	12
LUNG_SCLC	TNFRSF12A →	+2.704	+0.184	.001	<.001	3	12
BONE	SLC31A2 →	+1.569	+0.271	<.001	<.001	3	11
BONE	ITGA3 →	+5.151	+0.200	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140448 vs EXT2 — BONE

Explore this scatter interactively →