Signaling receptor ligand precursor processing

Across TCGA cell cohorts, RNA activity of the Signaling receptor ligand precursor processing pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF15, SDC4, and RBMX, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signaling receptor ligand precursor processing activity versus TAF15 in URINARY_TRACT (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TAF15 →	-0.686	-0.336	.002	.002	3	7
BONE	SDC4 →	+2.340	+0.342	.002	<.001	3	6
BLOOD_Leukemia	RBMX →	-0.579	-0.286	<.001	<.001	3	6
BLOOD_Leukemia	ZBTB39 →	-0.725	-0.268	<.001	<.001	3	6
BLOOD_Leukemia	ZBTB10 →	-0.793	-0.276	<.001	<.001	3	6
BONE	KLHL23 →	-1.735	-0.348	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140448 vs TAF15 — URINARY_TRACT

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