Antiviral innate immune response

Across TCGA patient cohorts, RNA activity of the Antiviral innate immune response pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP5, IFI44L, and RSAD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antiviral innate immune response activity versus GBP5 in BRCA (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBP5 →	+1.187	+0.187	.001	.001	3	6
LSCC	IFI44L →	+1.266	+0.246	<.001	<.001	3	6
BRCA	RSAD2 →	+1.309	+0.199	<.001	.002	3	6
LSCC	OAS2 →	+1.017	+0.242	<.001	<.001	3	5
LSCC	PLSCR1 →	+0.562	+0.220	.002	.001	3	5
BRCA	IFIH1 →	+0.934	+0.217	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140374 vs GBP5 — BRCA

Explore this scatter interactively →