Antiviral innate immune response

Across TCGA cell cohorts, RNA activity of the Antiviral innate immune response pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF774, CDC27, and NDUFB9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antiviral innate immune response activity versus ZNF774 in OESOPHAGUS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF774 →	+0.614	+0.311	.005	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CDC27 →	+0.766	+0.223	.008	.008	3	4
CNS	NDUFB9 →	+0.490	+0.168	.002	.004	3	4
BLOOD_Myeloma	RSAD1 →	+0.611	+0.211	.007	.001	3	4
LARGE_INTESTINE	RIDA →	+0.872	+0.172	<.001	<.001	3	4
BLOOD_Myeloma	IL34 →	-0.085	-0.265	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140374 vs ZNF774 — OESOPHAGUS

Explore this scatter interactively →