Antibacterial innate immune response

Across TCGA patient cohorts, RNA activity of the Antibacterial innate immune response pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LPXN, ADA2, and DOCK8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antibacterial innate immune response activity versus LPXN in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LPXN →	+0.634	+0.073	.004	.002	3	8
GBM	ADA2 →	+0.591	+0.151	<.001	<.001	3	8
GBM	DOCK8 →	+0.795	+0.183	<.001	<.001	3	8
LSCC	NECAP2 →	+0.209	+0.077	<.001	<.001	3	8
GBM	TRAF3IP3 →	+0.694	+0.103	<.001	.003	3	8
GBM	SASH3 →	+0.785	+0.173	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140367 vs LPXN — OV

Explore this scatter interactively →