Antibacterial innate immune response

Across TCGA patient cohorts, RNA activity of the Antibacterial innate immune response pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP5, TFEB, and GIMAP8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antibacterial innate immune response activity versus GIMAP5 in CCRCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GIMAP5 →	+0.445	+0.710	.003	.001	3	6
BRCA	TFEB →	+0.584	+0.530	<.001	.001	3	5
CCRCC	GIMAP8 →	+0.370	+0.585	.006	.001	3	5
CCRCC	GIMAP7 →	+0.823	+0.868	<.001	<.001	3	5
LSCC	ZC3H12D →	+0.328	+0.550	.009	.001	3	5
LSCC	RCSD1 →	+0.422	+0.702	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140367 vs GIMAP5 — CCRCC

Explore this scatter interactively →