Antibacterial innate immune response

Across TCGA cell cohorts, RNA activity of the Antibacterial innate immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHTF1, MCOLN1, and CD53, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHTF1 grouped by Antibacterial innate immune response-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PHTF1 →	+0.731	+0.653	.003	.002	3	4
LUNG_NSCLC_LUAD	MCOLN1 →	+0.493	+0.929	.001	.001	2	5
LARGE_INTESTINE	CD53 →	+0.360	+0.729	.001	.006	3	4
BLOOD_Lymphoma	EFNA2 →	+0.131	+1.704	.007	<.001	2	4
BLOOD_Myeloma	SEMA3C →	+0.899	+2.122	.007	<.001	2	4
SKIN	AMPD2 →	+0.522	+0.827	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHTF1 by Antibacterial innate immune response activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →