Antibacterial innate immune response

Across TCGA cell cohorts, RNA activity of the Antibacterial innate immune response pathway is significantly associated with the drug response of multiple features, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are LY2109761, GSK2578215A, and AT13148, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LY2109761 grouped by Antibacterial innate immune response-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	LY2109761 →	+0.548	+0.225	.002	.002	1	6
PANCREAS	GSK2578215A →	+1.110	+0.362	.029	.011	3	4
PANCREAS	AT13148 →	+0.955	+0.362	.010	.011	3	4
LUNG_NSCLC_LUAD	OTX015 →	+1.169	+0.716	.033	.020	3	3
LUNG_NSCLC_LUAD	GSK2830371A →	+0.251	+0.596	.030	.040	1	5
LUNG_NSCLC_LUAD	CPI-637 →	+0.809	+0.485	.023	.006	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LY2109761 by Antibacterial innate immune response activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →