Cyclic-GMP-AMP transmembrane import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Cyclic-GMP-AMP transmembrane import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BROX, NES_S790, and RASAL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclic-GMP-AMP transmembrane import across plasma membrane activity versus BROX in BRCA (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BROX →	-0.353	-0.043	<.001	.005	3	5
LSCC	NES_S790 →	+0.824	+0.066	<.001	<.001	3	5
CCRCC	RASAL2 →	+0.288	+0.081	<.001	<.001	3	5
HNSC	LRRC8C →	+0.475	+0.126	<.001	<.001	3	5
LUAD	RAPGEF1 →	+0.166	+0.048	<.001	.002	3	5
COAD	BCLAF3_S15 →	-0.268	-0.040	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140361 vs BROX — BRCA

Explore this scatter interactively →