Cyclic-GMP-AMP transmembrane import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Cyclic-GMP-AMP transmembrane import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WEE2, RNA5SP221, and SPATS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclic-GMP-AMP transmembrane import across plasma membrane activity versus WEE2 in COAD (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	WEE2 →	-0.101	-0.224	<.001	.005	3	3
UCEC	RNA5SP221 →	+0.673	+0.587	.002	.001	3	3
GBM	SPATS1 →	+0.098	+0.546	<.001	<.001	3	3
LUAD	FAM174B →	-0.487	-0.343	.001	.005	3	3
LUAD	STIMATE →	+0.107	+0.349	.003	.002	3	3
OV	RAP1BP3 →	+0.550	+0.652	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140361 vs WEE2 — COAD

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