Cyclic-GMP-AMP transmembrane import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Cyclic-GMP-AMP transmembrane import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2J3, TPM1, and SIDT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR2J3 grouped by Cyclic-GMP-AMP transmembrane import across plasma membrane-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	POLR2J3 →	+1.066	+1.066	.007	.001	3	4
LARGE_INTESTINE	TPM1 →	-1.404	-1.513	<.001	<.001	3	4
LARGE_INTESTINE	SIDT2 →	-0.794	-1.322	.001	<.001	3	4
SOFT_TISSUE	DENND6B →	-0.757	-1.558	.005	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ADAMTSL5 →	-0.966	-1.172	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	TMEM132A →	-1.607	-1.111	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR2J3 by Cyclic-GMP-AMP transmembrane import across plasma membrane activity — PANCREAS

Explore this box plot interactively →