Cyclic-GMP-AMP transmembrane import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Cyclic-GMP-AMP transmembrane import across plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFHX4, ALDH7A1, and MST1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFHX4 grouped by Cyclic-GMP-AMP transmembrane import across plasma membrane-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZFHX4 →	+0.238	+0.545	.002	<.001	3	4
CNS	ALDH7A1 →	+0.534	+0.474	.001	.006	2	4
LUNG_SCLC	MST1L →	-0.475	-0.367	<.001	.009	3	3
BREAST	PSMA3 →	+0.702	+0.562	.003	.001	3	3
BREAST	AURKC →	+0.134	+0.403	.004	<.001	3	3
OVARY	KLF11 →	-0.115	-0.268	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFHX4 by Cyclic-GMP-AMP transmembrane import across plasma membrane activity — BREAST

Explore this box plot interactively →