Cyclic-GMP-AMP transmembrane import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Cyclic-GMP-AMP transmembrane import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM4D, MYO6, and NUFIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cyclic-GMP-AMP transmembrane import across plasma membrane activity versus KDM4D in LARGE_INTESTINE (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KDM4D →	+0.529	+0.308	.003	.008	3	4
BREAST	MYO6 →	-1.658	-0.483	.005	.001	3	4
BREAST	NUFIP1 →	+0.569	+0.375	.001	.002	3	4
CNS	RPF2 →	-0.999	-0.406	<.001	.002	3	3
OESOPHAGUS	IFI30 →	-1.842	-0.951	.004	.008	3	3
LUNG_SCLC	DHRS12 →	+1.332	+0.395	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140361 vs KDM4D — LARGE_INTESTINE

Explore this scatter interactively →