Lipid import into cell

Across TCGA patient cohorts, RNA activity of the Lipid import into cell pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, DIS3, and PIGQ, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid import into cell activity versus IRS2 in OV (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IRS2 →	+1.472	+0.350	<.001	.003	3	9
COAD	DIS3 →	+0.349	+0.245	<.001	<.001	3	4
LUAD	PIGQ →	-0.439	-0.368	.002	.002	3	4
HNSC	TSKU →	+0.415	+0.206	.005	.005	3	4
GBM	GCLM →	+0.420	+0.167	.001	.003	3	4
LSCC	NUFIP2 →	+0.441	+0.264	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140354 vs IRS2 — OV

Explore this scatter interactively →