Lipid import into cell

Across TCGA cell cohorts, RNA activity of the Lipid import into cell pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HELZ2, TNFAIP2, and ARHGAP23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HELZ2 grouped by Lipid import into cell-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HELZ2 →	-1.090	-1.081	.007	.004	3	5
OVARY	TNFAIP2 →	-3.749	-1.622	<.001	<.001	3	5
LUNG_SCLC	ARHGAP23 →	-2.480	-1.478	.001	.001	3	5
SOFT_TISSUE	ACTB →	-1.019	-1.838	.005	<.001	3	5
LUNG_SCLC	MYH9 →	-1.951	-1.506	.008	.001	3	5
SOFT_TISSUE	ABHD5 →	-1.218	-1.533	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HELZ2 by Lipid import into cell activity — OVARY

Explore this box plot interactively →