Lipid import into cell

Across TCGA cell cohorts, RNA activity of the Lipid import into cell pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A1, EIF4EBP1, and RPL18A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid import into cell activity versus SLC2A1 in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC2A1 →	+0.933	+0.842	<.001	<.001	3	6
LUNG_SCLC	EIF4EBP1 →	-0.722	-0.765	<.001	.007	3	5
BLOOD_Lymphoma	RPL18A →	-0.651	-1.022	.001	.001	3	4
BLOOD_Lymphoma	RPS8 →	-0.521	-0.970	.002	<.001	3	4
BONE	RPUSD4 →	-0.663	-1.241	.003	.001	3	4
BONE	MAPT →	-6.930	-1.921	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140354 vs SLC2A1 — BLOOD_Leukemia

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