Lipid export from cell

Across TCGA patient cohorts, RNA activity of the Lipid export from cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMP9, ATF7IP_S113, and PADI4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid export from cell activity versus MMP9 in GBM (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMP9 →	+0.965	+0.047	.002	.005	3	8
GBM	ATF7IP_S113 →	-0.667	-0.052	<.001	<.001	3	7
GBM	PADI4 →	+1.177	+0.064	<.001	<.001	3	7
BRCA	PRTN3 →	+0.746	+0.020	.005	.005	3	7
BRCA	SRFBP1_S203 →	-0.710	-0.026	<.001	.001	3	6
LSCC	ZC3H18_S534 →	-0.805	-0.057	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140353 vs MMP9 — GBM

Explore this scatter interactively →