Lipid export from cell

Across TCGA patient cohorts, RNA activity of the Lipid export from cell pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, FN1, and SLC16A3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid export from cell activity versus SPP1 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPP1 →	+1.802	+0.383	<.001	<.001	3	8
HNSC	FN1 →	+1.268	+0.709	.001	<.001	3	7
BRCA	SLC16A3 →	+0.840	+0.473	<.001	.001	3	7
GBM	ITGAM →	+0.872	+0.429	<.001	<.001	3	7
LSCC	TREML3P →	+0.864	+0.240	<.001	<.001	3	7
GBM	SLC11A1 →	+1.071	+0.401	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140353 vs SPP1 — LSCC

Explore this scatter interactively →