Lipid export from cell

Across TCGA cell cohorts, RNA activity of the Lipid export from cell pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPIN1, RNF139, and YIF1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid export from cell activity versus SPIN1 in BREAST (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SPIN1 →	-1.148	-1.686	.004	<.001	3	3
SKIN	RNF139 →	-0.591	-1.260	.001	<.001	3	3
URINARY_TRACT	YIF1B →	+0.804	+1.568	.004	.003	3	3
BLOOD_Myeloma	MARK4 →	+1.500	+1.575	.009	<.001	2	4
PANCREAS	MDGA1 →	+2.022	+1.517	.003	<.001	3	3
PANCREAS	TATDN1 →	-1.012	-1.528	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140353 vs SPIN1 — BREAST

Explore this scatter interactively →