Aminophospholipid translocation

Across TCGA patient cohorts, RNA activity of the Aminophospholipid translocation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPD1L, NCOA7, and NCOA7_S211, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminophospholipid translocation activity versus GPD1L in HNSC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GPD1L →	+0.530	+0.072	.001	.006	3	7
GBM	NCOA7 →	+0.347	+0.056	<.001	.002	3	6
GBM	NCOA7_S211 →	+0.522	+0.073	.001	.001	3	6
BRCA	PLCL2 →	+0.369	+0.058	<.001	<.001	3	6
HNSC	ELP3 →	-0.221	-0.082	.001	<.001	3	6
PDAC	PHACTR2 →	+0.368	+0.088	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140331 vs GPD1L — HNSC

Explore this scatter interactively →