Aminophospholipid translocation

Across TCGA patient cohorts, RNA activity of the Aminophospholipid translocation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR223HG, ATP8A1, and P2RY12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminophospholipid translocation activity versus MIR223HG in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MIR223HG →	+0.802	+0.218	.001	.002	2	5
GBM	ATP8A1 →	+1.137	+0.323	<.001	<.001	3	4
GBM	P2RY12 →	+0.952	+0.306	<.001	.001	3	4
LSCC	PSMB8 →	+0.493	+0.270	.001	.006	3	3
LSCC	RPSAP75 →	+0.420	+0.177	.007	.003	3	3
LSCC	TSPAN15 →	+0.405	+0.228	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140331 vs MIR223HG — LSCC

Explore this scatter interactively →