Regulation protein catabolic process at synapse

Across TCGA patient cohorts, RNA activity of the Regulation protein catabolic process at synapse pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IMPDH1P6, ZNF394, and KLHDC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation protein catabolic process at synapse activity versus IMPDH1P6 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IMPDH1P6 →	+0.228	+0.139	.002	<.001	3	3
CCRCC	ZNF394 →	+0.202	+0.185	<.001	.004	3	3
CCRCC	KLHDC2 →	+0.319	+0.225	<.001	<.001	3	3
LSCC	BTF3P5 →	+0.276	+0.564	.005	<.001	3	3
PDAC	IGHV1-45 →	-0.716	-0.538	.001	<.001	3	2
OV	IGKV1-13 →	-0.837	-0.165	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140250 vs IMPDH1P6 — GBM

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