Regulation protein catabolic process at synapse

Across TCGA cell cohorts, RNA activity of the Regulation protein catabolic process at synapse pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM3, DKK1, and POLR1H, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM3 grouped by Regulation protein catabolic process at synapse-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RBM3 →	-0.939	-0.959	.002	<.001	3	4
CNS	DKK1 →	-3.122	-0.907	.002	.002	3	4
CNS	POLR1H →	+0.549	+0.901	.004	.007	3	4
UPPER_AERODIGESTIVE_TRACT	DNAAF2 →	+1.017	+1.384	.003	.006	3	3
URINARY_TRACT	PLEKHG4 →	+2.186	+1.496	.005	<.001	3	3
LARGE_INTESTINE	EGFL8 →	+0.937	+1.151	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM3 by Regulation protein catabolic process at synapse activity — PANCREAS

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