Regulation of translation at synapse

Across TCGA patient cohorts, RNA activity of the Regulation of translation at synapse pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOB, H2BW3P, and LRRC32, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translation at synapse activity versus RHOB in LUAD (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RHOB →	-1.029	-0.208	<.001	<.001	3	4
LUAD	H2BW3P →	-0.255	-0.159	.002	<.001	3	4
OV	LRRC32 →	-1.042	-0.493	.002	.001	3	4
UCEC	RNVU1-25 →	-0.907	-0.249	.004	.006	2	5
PDAC	SOCS3 →	-0.385	-0.273	.006	.003	3	4
GBM	NTNG2 →	-0.563	-0.146	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140243 vs RHOB — LUAD

Explore this scatter interactively →