Regulation of translation at synapse

Across TCGA cell cohorts, RNA activity of the Regulation of translation at synapse pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCI, MEF2D, and KLLN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCI grouped by Regulation of translation at synapse-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRKCI →	-0.708	-0.189	.001	<.001	3	4
LUNG_NSCLC_LUAD	MEF2D →	-0.968	-0.195	<.001	.001	3	4
BLOOD_Leukemia	KLLN →	-0.518	-0.094	.003	.005	3	4
LARGE_INTESTINE	ABHD15 →	-0.509	-0.125	.004	.005	3	4
PANCREAS	BCDIN3D →	-0.524	-0.132	.002	<.001	3	3
PANCREAS	FSCN2 →	-0.705	-0.132	<.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCI by Regulation of translation at synapse activity — LUNG_SCLC

Explore this box plot interactively →