Regulation of translation at synapse

Across TCGA cell cohorts, RNA activity of the Regulation of translation at synapse pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FXR1, YEATS2, and GPRIN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translation at synapse activity versus FXR1 in LUNG_NSCLC_LUSC (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FXR1 →	+1.578	+0.312	.003	<.001	3	7
LUNG_NSCLC_LUSC	YEATS2 →	+1.954	+0.351	.007	.002	3	6
LUNG_SCLC	GPRIN1 →	+0.821	+0.224	.003	<.001	3	6
BREAST	NUF2 →	+1.106	+0.266	<.001	.001	3	6
LARGE_INTESTINE	OAZ2 →	+0.814	+0.183	.001	<.001	3	6
LUNG_SCLC	SLC4A8 →	+1.236	+0.297	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140243 vs FXR1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →