Regulation of long-chain fatty acid import into cell

Across TCGA patient cohorts, RNA activity of the Regulation of long-chain fatty acid import into cell pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, CDC16, and CARS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-chain fatty acid import into cell activity versus IRS2 in OV (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IRS2 →	+1.417	+0.768	<.001	.001	2	8
LSCC	CDC16 →	+0.519	+0.580	.002	.001	3	4
LSCC	CARS2 →	+0.531	+0.740	<.001	<.001	3	4
LSCC	ING1 →	+0.488	+0.537	.007	.009	3	4
LSCC	FGFR3 →	-1.051	-0.629	.001	.001	3	4
LSCC	ANKRD10 →	+0.698	+0.598	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140212 vs IRS2 — OV

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