Regulation of long-chain fatty acid import into cell

Across TCGA patient cohorts, RNA activity of the Regulation of long-chain fatty acid import into cell pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IRS2_S560, IRS2_S577, and IRS2_S594, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-chain fatty acid import into cell activity versus IRS2_S560 in CCRCC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IRS2_S560 →	+0.856	+1.017	<.001	<.001	3	9
BRCA	IRS2_S577 →	+1.060	+1.193	<.001	<.001	3	9
OV	IRS2_S594 →	+1.706	+1.057	<.001	<.001	3	8
LSCC	IRS2 →	+0.928	+0.927	<.001	<.001	3	7
PDAC	IRS2_S365 →	+1.092	+0.647	<.001	.001	2	8
LUAD	IRS2_S1100 →	+1.409	+0.534	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140212 vs IRS2_S560 — CCRCC

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