Regulation of long-chain fatty acid import into cell

Across TCGA cell cohorts, RNA activity of the Regulation of long-chain fatty acid import into cell pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB5B, CAVIN1, and PADI2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYB5B grouped by Regulation of long-chain fatty acid import into cell-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CYB5B →	-1.089	-1.236	.003	<.001	3	6
OVARY	CAVIN1 →	-1.412	-1.066	.005	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PADI2 →	+1.641	+1.687	.001	<.001	3	4
LUNG_NSCLC_LUSC	COL27A1 →	+1.978	+1.368	.005	<.001	3	4
OVARY	PTMS →	-1.301	-1.016	.001	<.001	3	4
OVARY	PEAK1 →	-0.964	-0.893	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYB5B by Regulation of long-chain fatty acid import into cell activity — SOFT_TISSUE

Explore this box plot interactively →