Oligopeptide import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Oligopeptide import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC15A3, NCF2, and ITGB2, each associated with the pathway in up to 22 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligopeptide import across plasma membrane activity versus SLC15A3 in SCLC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	SLC15A3 →	+1.633	+0.249	<.001	<.001	3	22
SCLC	NCF2 →	+2.460	+0.213	<.001	<.001	3	20
SCLC	ITGB2 →	+1.962	+0.206	<.001	<.001	3	20
LGG	LGALS9 →	+1.406	+0.102	<.001	<.001	3	20
SCLC	CD74 →	+2.257	+0.254	<.001	<.001	3	20
SCLC	HCK →	+1.601	+0.238	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140205 vs SLC15A3 — SCLC

Explore this scatter interactively →