Oligopeptide import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Oligopeptide import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM92-AS1, A2ML1, and SLC7A11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligopeptide import across plasma membrane activity versus TMEM92-AS1 in CCRCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TMEM92-AS1 →	+0.664	+0.775	.005	<.001	2	5
PDAC	A2ML1 →	+1.331	+0.703	.001	.003	3	4
HNSC	SLC7A11 →	+1.065	+0.825	<.001	<.001	3	4
LUAD	CTSD →	+0.562	+0.406	.001	.005	3	3
LUAD	CHST6 →	+0.946	+0.404	.002	.004	3	3
LUAD	CCDC196 →	-0.491	-0.263	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140205 vs TMEM92-AS1 — CCRCC

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