Oligopeptide import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Oligopeptide import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC15A4_S298, SLC15A4, and TP53BP1_S208, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligopeptide import across plasma membrane activity versus SLC15A4_S298 in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC15A4_S298 →	+1.166	+0.253	<.001	<.001	3	5
BRCA	SLC15A4 →	+0.863	+0.245	<.001	<.001	3	4
BRCA	TP53BP1_S208 →	-1.266	-0.210	<.001	<.001	2	4
OV	UBL7_S230 →	-0.923	-1.017	<.001	<.001	3	3
HNSC	SLC7A11_S26 →	+1.048	+0.863	<.001	<.001	3	3
PDAC	SLC16A3 →	+0.647	+0.947	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140205 vs SLC15A4_S298 — BRCA

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