Positive regulation of lymphocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive regulation of lymphocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERV3-1, N4BP2, and HMCES, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lymphocyte chemotaxis activity versus ERV3-1 in CNS (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ERV3-1 →	-1.136	-1.013	.003	.001	3	4
BLOOD_Leukemia	N4BP2 →	+0.871	+0.526	.004	.004	2	4
SOFT_TISSUE	HMCES →	+1.047	+1.543	<.001	.002	3	3
SOFT_TISSUE	HNRNPUL2 →	+0.612	+1.207	.003	.002	3	3
LARGE_INTESTINE	TMEM14C →	-0.622	-1.020	<.001	<.001	3	3
LARGE_INTESTINE	MITF →	-0.908	-0.837	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140131 vs ERV3-1 — CNS

Explore this scatter interactively →