Export across plasma membrane

Across TCGA patient cohorts, RNA activity of the Export across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCA5, WDHD1, and CRYL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Export across plasma membrane activity versus SMARCA5 in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMARCA5 →	-0.275	-0.034	<.001	<.001	3	7
GBM	WDHD1 →	-0.449	-0.031	<.001	<.001	3	7
UCEC	CRYL1 →	+0.413	+0.049	<.001	<.001	3	7
UCEC	DAXX →	-0.251	-0.062	<.001	<.001	3	7
GBM	PRPF40A →	-0.251	-0.034	<.001	<.001	3	7
BRCA	RIF1_S782 →	-0.984	-0.046	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140115 vs SMARCA5 — GBM

Explore this scatter interactively →