Export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBF4B, NOD2, and INTS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Export across plasma membrane activity versus DBF4B in LARGE_INTESTINE (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DBF4B →	-0.672	-0.288	.001	.003	3	5
BLOOD_Leukemia	NOD2 →	+0.724	+0.669	.008	<.001	3	4
SKIN	INTS2 →	-0.532	-0.258	.006	<.001	3	4
SKIN	LMNB2 →	-0.524	-0.183	.007	.002	3	4
URINARY_TRACT	KIF18B →	-1.073	-0.366	.002	.007	3	4
SOFT_TISSUE	STK24 →	+0.944	+0.267	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140115 vs DBF4B — LARGE_INTESTINE

Explore this scatter interactively →