Export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Export across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP1A1, ATP4A, and ATP1B3, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Export across plasma membrane activity versus ATP1A1 in PANCREAS (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ATP1A1 →	+0.918	+0.347	<.001	<.001	3	16
LUNG_SCLC	ATP4A →	+1.420	+0.669	<.001	<.001	3	13
PANCREAS	ATP1B3 →	+1.343	+0.323	.003	.002	2	9
OVARY	NAP1L4 →	-0.957	-0.663	.009	.002	3	7
LUNG_SCLC	ATP1B1 →	+1.681	+0.580	.001	.004	3	7
URINARY_TRACT	COMMD2 →	-1.782	-0.310	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140115 vs ATP1A1 — PANCREAS

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