Dendrite arborization

Across TCGA patient cohorts, RNA activity of the Dendrite arborization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOC2L_S672, RRP1, and SPTAN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendrite arborization activity versus NOC2L_S672 in LUAD (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NOC2L_S672 →	-0.430	-0.102	.001	<.001	3	6
BRCA	RRP1 →	-0.376	-0.064	<.001	<.001	3	5
BRCA	SPTAN1 →	+0.259	+0.060	.003	.001	3	5
UCEC	SPTBN1 →	+0.221	+0.094	.002	<.001	3	5
LSCC	KNSTRN →	-0.599	-0.076	.001	.003	3	5
BRCA	PTN →	+0.824	+0.062	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0140059 vs NOC2L_S672 — LUAD

Explore this scatter interactively →